Meanings
(become worse): The origin is unclear. Common belief attributes it to the standard orientation of maps, where south is the downwards direction. Alternatively, it could stem from a euphemism used by some Native Americans for dying.[1]
How to pronounce "go south":
AU
To become unfavorable; to decrease; to take a turn for the worse.
Example: "I should have walked away from the casino when my luck went south, but I stayed and ended up in the hole."
To make an escape; to disappear.
To give somebody oral sex.