Definitions
There are 2 meanings of the phrase
Main Street.
Main Street - as a noun
Street that serves as a principal thoroughfare for traffic in a town
Synonyms (Exact Relations)
high streetHypernyms (Closely Related)
streetHyponyms (Broadly Related)
Any small town (or the people who inhabit it); generally used to represent parochialism and materialism (after a novel by sinclair lewis)
Example: "Main street will never vote for a liberal politician"