LITTLE SIOUX RIVER(noun)Did you mean?RhymesDefinitions There is 1 meaning of the phrase Little Sioux River. Little Sioux River - as a noun A river that rises in southwestern minnesota and flows southwestward to the missouri river in western iowa Word Variations & RelationsStarts LStarts LIStarts LITStarts LITTEnds REnds EREnds VEREnds IVERStarts L & ends RStarts LI & ends RStarts L & ends ERA-Z Proximitieslittermate12littermates13litters7littery10little6 Little Sioux River little-knownlittleneck16littlenecks17littleness10littlenesses12