Anagrams of: TREPANATION

• A soft Italian sourdough brioche from Milan, with candied fruit, usually prepared for Christmas as a dessert.

• a poisonous crystalline alkaloid extracted from the nightshade family; used as an antispasmodic and to dilate the eye pupil; also administered in large amounts as an antidote for organophosphate nerve agents or organophosphate insecticides

• coat with a patina

• To assume control of (a governmental power) from a former mother country.

• enduring trying circumstances with even temper or characterized by such endurance

• a person who requires medical care

• the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause