• son of Edward II and King of England from 1327-1377; his claim to the French throne provoked the Hundred Years' War; his reign was marked by an epidemic of the Black Plague and by the emergence of the House of Commons as the powerful arm of British Parliament (1312-1377)
• Italian pope from 1198 to 1216 who instituted the Fourth Crusade and under whom papal intervention in European politics reached its height (1160-1216)
• King of England from 1483 to 1485; seized the throne from his nephew Edward V who was confined to the Tower of London and murdered; his reign ended when he was defeated by Henry Tudor (later Henry VII) at the battle of Bosworth Field (1452-1485)
• an analgesic for mild pain but not for inflammation; also used as an antipyretic; (Datril, Tylenol, Panadol, Phenaphen, Tempra, and Anacin III are trademarks of brands of acetaminophen tablets)
• Italian antipope from 1080 to 1100 who was installed as pope by the Holy Roman Emperor Henry IV who consistently opposed efforts at papal reform (died in 1100)
• King of Great Britain and Ireland from 1760 to 1820; the American colonies were lost during his reign; he became insane in 1811 and his son (later George IV) acted as regent until 1820 (1738-1820)
• son of Henry VII and King of England from 1509 to 1547; his divorce from Catherine of Aragon resulted in his break with the Catholic Church in 1534 and his excommunication 1538, leading to the start of the Reformation in England (1491-1547)
• Italian pope from 1534 to 1549 who excommunicated Henry VIII of England in 1538 and initiated the Council of Trent in 1545; was active in the Counter Reformation and promoted the Society of Jesus for this purpose (1468-1549)
• a large clinical trial of a treatment or drug that in phase I and phase II has been shown to be efficacious with tolerable side effects; after successful conclusion of these clinical trials it will receive formal approval from the FDA
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